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Usefulness of Pallidotomy in Advanced Parkinson's Disease JNNP 62:125-132, Johansson,F.,et al, 1997 See this aricle in Pubmed Article Abstract There were no serious adverse events of surgery.Two of the 22 patients could not complete all the tests after operation.The proportion of dyskinesia periods decreased in the 20 patients and there was a proportional increase in normal or fairly normal occasions."Off"periods were not significantly affected.In 12 of 13 patients with limb dyskinesia this symptom was completely abolished in the contralateral limbs.There was also some degree of improvement axially and ipsilaterally.Tremor was moderately improved contralaterally.Bradykinesia remained unchanged. Results at 12 months followup were similar to those at 4 months. Pallidotomy produced a pronounced positive effect on dyskinesia and a moderate effect on tremor.Bradykinesia was not affected.Posteroventral pallidotomy may be useful in patients with Parkinson's disease who have severe motor fluctuations and may allow an increase in levodopa dose to alleviate bradykinesia in"off"states.

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